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Of note, another study performed in rats demonstrated the role of the transporter in maintaining astrocytic plasticity in the central nucleus of the amygdala and in responding to withdrawal from ethanol exposure, the latter manifesting in upregulation of GAT3 and changes in GAT3-sensitive tonic GABA currents [174]

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Abstract γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system (CNS), regulates neuronal excitability, synaptic plasticity, and oscillatory activity essential for cognition, emotion, and behavior