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Ferroptosis in Kidney Disease—A Promising Therapeutic Target In 2014, researchers showed that global genetic deletion of Gpx4 in adult mice results in lethality, with massive proximal tubule cell death, demonstrating that proximal tubule cells are among the most vulnerable cell types to ferroptotic stress

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Neuroprotection Induced by N-Acetylcysteine against Cytosolic Glutathione Depletion-Induced Ca2+ Influx in Dorsal Root Ganglion Neurons of Mice: Role of TRPV1 Channels