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The key reducing equivalents for ribonucleotide reductase (RNR), which catalyzes the conversion of nucleoside diphosphates (NDPs) to deoxyribonucleoside diphosphates (dNDPs) in order to construct the deoxyribonucleoside triphosphate (dNTP) pool required for DNA replication, are specifically provided by reduced nicotinamide adenine dinucleotide phosphate (NADPH) (120)

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(2004) Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support Blood, 103, 3349-3354 44