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Although this proportion is broadly consistent with that observed during substantial weight loss induced by lifestyle interventions or other obesity management therapies, it is not negligible and warrants careful consideration

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Key molecular effects: Fibroblast activation — Collagen I, III, VI synthesis upregulated at nanomolar concentrations Angiogenesis — VEGF-A and VEGFR-2 upregulation promotes capillary formation in wound beds Antioxidant induction — SOD1 and catalase gene activation reduces oxidative burden Inflammation modulation — IL-6 and TNF-α suppression