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However, in rat, mouse and human cerebrospinal fluid (CSF) that is assumed to reflect the metabolism of neurotransmitters, DA-glucuronide and sulfate conjugates have been found (Wang et al., Figure 3 UGT isoforms involved in dopamine and serotonin glucuronidation Among 22 recombinant human UGTs, only UGT1A10 was found to catalyze DA glucuronidation at substantial rate although with a low affinity, leading to the formation of both 4-O- and 3-O-glucuronide (Itäaho et al., Physiological significance of neurotransmitters glucuronidation in brain The main excretion products of DA found in human urine are HVA, DOPAC, their sulfates and glucuronides, as well as DA conjugates
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It is driven by the high pharmaceutical and biotechnology industry in addition to high investments in R&D and regulatory framework
