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doi: 10.1146/annurev-genom-082509-141720 75 DominyJEPuigserverP

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[116], the increased production of superoxide radicals (O 2 •− ) resulting from T2D hyperglycemia can rapidly react with nitric oxide (NO) to produce peroxynitrite (ONOO − ), which can subsequently react with protein (and apolipoprotein) tyrosine residues to form 3-nitro-tyrosine (3-NT)

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