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Central to neutrophil-mediated protection is miRNA-223, a neutrophil-derived microRNA that orchestrates anti-inflammatory responses ( Figure 4B )

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Whereas urate effectively inhibited peroxynitrite-mediated 4-hydroxyphenylacetic acid nitration (IC 50 100 µM) in the presence of CO 2 [92], it was ineffective against tyrosine nitration in bovine serum albumin [95], suggesting that the protective effect of urate depends on the competing substrate for nitration