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Since mitochondrial metabolism is prevalent in normal high-energy-demand tissues, such as the heart and liver, OXPHOS inhibitors (e.g., IACS-010759) have shown dose-limiting toxicities (DLT) in some clinical trials, hindering their widespread application [173]

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This means it helps neutralize toxins that have already been processed, making them water-soluble so they can be safely removed from the body