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The committee members who voted yes generally believed the risks to be minimal, while those who voted no tended to worry about safety risks and effectiveness, and expressed concern that adding the peptide to the compounding list would create a false impression that it has been evaluated with the same rigorous standards as an FDA-approved drug

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In primary cultures of alveolar epithelial cells from Nrf2 − / − mice, the higher levels of ROS result in activation of the ataxia telangiectasia mutated DNA damage-response pathway and impaired cell cycle progression, with the mutant cells exhibiting G 2 /M-phase arrest and fewer cells in S-phase [155]